At such scales, the classical Navier-Stokes paradigm no longer provides an accurate description of the flow physics; however, microscopic models such as molecular dynamics (MD) become computationally intractable for most flows of practical interest.  In this talk talk I will consider the influence of thermal fluctuations, which we will see are key to understanding counter-intuitive phenomena in nanoscale interfacial flows.   A `top down’ framework that incorporates thermal noise is provided by fluctuating hydrodynamics and we shall use this model to gain insight into interfacial nanoflows such as drop coalescence, jet breakup and thin film rupture, using MD as a benchmark.