{"id":242,"date":"2011-01-26T02:11:08","date_gmt":"2011-01-26T02:11:08","guid":{"rendered":"http:\/\/www.wi.rwth-aachen.de\/SmartMedCN\/?p=242"},"modified":"2011-01-26T02:11:08","modified_gmt":"2011-01-26T02:11:08","slug":"incomplete-drug-test-report-increases-adr","status":"publish","type":"post","link":"https:\/\/blog.rwth-aachen.de\/smartmedcn\/2011\/01\/26\/incomplete-drug-test-report-increases-adr\/","title":{"rendered":"Incomplete Drug Test Report Increases ADR"},"content":{"rendered":"<p><span style=\"color: #333399\"><em><strong>2011-01-26<\/strong><\/em><\/span><\/p>\n<p><strong>To prove the effectiveness and drug safety, pharmaceutical manufaturers are required make an report regarding the clinique tests of new drugs.\u00a0\u00a0 However, it turns out that manufacturers often only report about the good news or emphasizes and advantages, whereas adverse drug reaction (ADR) is often ignored. The so called &#8220;publication bias&#8221; will misguide doctors and the public, which may lead to some safety problems. As a matter of fact, in the past year many pharmaceutical manufacturers called back their products for this reason.<\/strong><\/p>\n<p>&nbsp;<\/p>\n<h3>\u836f\u5382\u64cd\u7eb5\u4e34\u5e8a\u8bd5\u9a8c\u5bfc\u81f4\u53d1\u8868\u504f\u501a\uff1a\u62a5\u559c\u4e0d\u62a5\u5fe7<\/h3>\n<p>2011-01-26 \u6765\u6e90\uff1a\u533b\u836f\u7ecf\u6d4e\u62a5 \u5927 | \u4e2d | \u5c0f<\/p>\n<p>\u6838\u5fc3\u63d0\u793a\uff1a\u4e3a\u4e86\u8bc1\u660e\u836f\u7269\u5b89\u5168\u6709\u6548\uff0c\u5236\u836f\u516c\u53f8\u5728\u5b8c\u6210\u4e34\u5e8a\u8bd5\u9a8c\u4ee5\u540e\uff0c\u5fc5\u987b\u5c06\u8bd5\u9a8c\u7ed3\u679c\u4e0a\u62a5\u56fd\u5bb6\u836f\u54c1\u76d1\u7763\u673a\u5173\u5ba1\u6838\u6279\u51c6\uff0c\u5e76\u5c06\u8bd5\u9a8c\u7ed3\u679c\u516c\u5e03\u4e8e\u4f17\u3002\u4f46\u7531\u4e8e\u5236\u836f\u516c\u53f8\u81ea\u59cb\u81f3\u7ec8\u63a7\u5236\u4e34\u5e8a\u8bd5\u9a8c\uff0c\u638c\u63e1\u8bd5\u9a8c\u6570\u636e\uff0c\u4ed6\u4eec\u4f1a\u5c3d\u53ef\u80fd\u5c11\u5730\u516c\u5e03\u5bf9\u81ea\u5df1\u4e0d\u5229\u7684\u7ed3\u679c\uff0c\u8fd9\u5c31\u662f\u5728\u5236\u836f\u516c\u53f8\u4e2d\u76db\u884c\u7684\u53d1\u8868\u504f\u501a\u3002<br 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Vedula\u7b49\u5bf920\u4e2a\u7531\u8f89\u745e\u548c\u6d3e\u5fb7\u5236\u836f\u63d0\u4f9b\u8d44\u91d1\u7684\u52a0\u5df4\u55b7\u4e01\u4e34\u5e8a\u8bd5\u9a8c\u8fdb\u884c\u9274\u522b\u7814\u7a76,\u5e76\u4e14\u83b7\u5f97\u4e86\u8fd9\u4e9b\u8bd5\u9a8c\u7684\u5185\u90e8\u8d44\u6599\u3002\u7ed3\u679c\u53d1\u73b0,\u8fd920\u4e2a\u4e34\u5e8a\u8bd5\u9a8c\u5bf9\u5916\u4ec5\u516c\u5e03\u4e8612\u4e2a\u3002<\/p>\n<p>\u9009\u62e9\u6709\u5229\u7684\u8bd5\u9a8c\u7ed3\u679c\u53d1\u8868<\/p>\n<p>1991\u5e74,\u7b2c\u4e00\u4e2a\u6cbb\u7597\u6025\u6027\u504f\u5934\u75db\u7684\u66f2\u5766\u7c7b\u836f\u7269\u8212\u9a6c\u666e\u5766\u5728\u6b27\u6d32\u4e0a\u5e02,\u57281994~1995\u5e74\u95f4,\u5fb7\u56fd\u548c\u6cd5\u56fd\u6709\u7814\u7a76\u8005\u4f7f\u752825mg\u7684\u8212\u9a6c\u666e\u5766\u6813\u5242\u4e0e\u9ea6 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1990~1991\u5e74\u95f4,\u4e5f\u5c31\u662f\u8212\u9a6c\u666e\u5766\u63a8\u5411\u5e02\u573a\u524d,\u845b\u5170\u7d20\u53f2\u514b\u5728\u82f1\u56fd\u505a\u8fc7100mg\u5242\u91cf\u7684\u8212\u9a6c\u666e\u5766\u7684\u53e3\u670d\u836f\u8bd5\u9a8c,\u4ee5\u4e3b\u8981\u7597\u6548\u6807\u51c6\u8bc4\u4f30,\u5728\u4f17\u591a\u6b21\u4e34\u5e8a\u8bd5\u9a8c \u4e2d\u53ea\u6709\u4e00\u4e2a\u8bd5\u9a8c\u7684\u6709\u6548\u7387\u8d85\u8fc7\u4e8650%,\u800c\u5728\u76f4\u80a0\u7ed9\u836f\u8bd5\u9a8c\u4e2d,\u8212\u9a6c\u666e\u5766\u7684\u6548\u679c\u4e5f\u6b21\u4e8e\u9ea6\u89d2\u80fa\u3002\u8fd9\u4e9b\u7ed3\u8bba\u4ece\u672a\u5bf9\u5916\u516c\u5e03\u8fc7,\u6bd5\u7adf\u8fd9\u6837\u7684\u7ed3\u679c\u5bf9\u4e8e\u4e00\u4e2a\u5373\u5c06\u63a8\u5411\u5e02\u573a\u7684 \u65b0\u836f\u6765\u8bf4,\u65e0\u7591\u662f\u4e0d\u5229\u7684\u3002<\/p>\n<p>Turner\u7b49\u5bf9FDA\u7f51\u7ad9\u4e0a\u516c\u5e03\u768412\u79cd\u975e\u4e09\u73af\u7c7b\u6297\u6291\u90c1\u836f 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